Large-scale inference of the point mutational spectrum in human segmental duplications
نویسندگان
چکیده
منابع مشابه
Bayesian Estimation and Inference of Large-Scale Duplications
Background Recent analysis of eukaryotic genomes shows that genome duplication has occurred multiple times in fish, plants and yeast. This thesis presents a Bayesian procedure for estimating and inferring the timing of largescale duplications. The estimation procedure calculates the expected number of duplications over each edge in a discretized species tree, to find sites where many duplicatio...
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Primate-specific segmental duplications are considered important in human disease and evolution. The inability to distinguish between allelic and duplication sequence overlap has hampered their characterization as well as assembly and annotation of our genome. We developed a method whereby each public sequence is analyzed at the clone level for overrepresentation within a whole-genome shotgun s...
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The high level of gene redundancy that characterizes eukaryotic genomes results in part from segmental duplications. Spontaneous duplications of large chromosomal segments have been experimentally demonstrated in yeast. However, the dynamics of inheritance of such structures and their eventual fixation in populations remain largely unsolved. We analyzed the stability of a vast panel of large se...
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15 صفحه اولPhylogenomic analysis reveals ancient segmental duplications in the human genome.
Evolution of organismal complexity and origin of novelties during vertebrate history has been widely explored in context of both regulation of gene expression and gene duplication events. Ohno (1970) for the first time put forward the idea of two rounds whole genome duplication events as the most plausible explanation for evolutionarizing the vertebrate lineage (2R hypothesis). To test the vali...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2009
ISSN: 1471-2164
DOI: 10.1186/1471-2164-10-43